Following an intensive planning, procurement, and installation phase, the time has now come: all instruments are fully operational and available for research.
The new infrastructure significantly expands the technological portfolio of the Core Facilities and opens up new possibilities for performing and analyzing multi-omics analyses of biomedical samples. The systems now available are:
MACSima™: This automated system enables the spatially and subcellularly resolved analysis of tissue and cell samples using highly multiplexed, stepwise immunofluorescence staining (>200 proteins, 27 RNAs). This allows cell types, expression patterns, and cell interactions to be identified and analyzed directly within the tissue context.
cellenONE™: This system enables the highly precise, automated isolation and dispensing of single cells, cell clusters, or subcellular components using optical detection and piezo-based liquid handling technology. It allows gentle and reproducible sample processing for downstream single-cell and multi-omics applications, particularly for single-cell proteomics. By combining high accuracy, flexibility, and minimal sample requirements, the system is especially well suited for challenging samples and experimental designs with the highest quality requirements.
Xenium: The Xenium platform is a microscopy-based spatial transcriptomics technology for the spatial visualization of RNA and proteins at subcellular resolution directly in tissue sections, enabling the study of cell-cell interactions and tissue architecture. It allows thousands of genes to be localized simultaneously, high-resolution images to be generated, cell types to be identified, and disease mechanisms, such as in cancer or neurodegenerative diseases, to be investigated at the microscopic level — an essential aspect of precision medicine.
HPC hardware: As part of this project, CPU and GPU hardware as well as storage media were acquired and integrated into the MedUni Scientific Cluster (MSC) at the ITSC. These resources are already being used by MUW researchers to analyze multi-omics data as well as other large datasets.
Detailed information on the individual systems, fields of application, booking options, and contact persons can be found, as usual, on the Core Facilities websites or obtained directly from the respective teams.
We look forward to using this new infrastructure together with you and to the exciting research projects that will emerge from it.
Best regards,
The Core Facilities Team